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Apes are a superfamily of highly intelligent anthropoids.

Ape or APE may also refer to:

People

Ape (plant), the Polynesian name for the giant taro plant
Xanthosoma ('ape), tropical American plant
Acute pulmonary edema, fluid accumulation on the lungs
Anomalous photovoltaic effect, a type of a photovoltaic effect which occurs in semiconducting materials
AP Environmental Science, the environmental science course in the Advanced Placement program
Available potential energy, or convective available potential energy, the energy a parcel of air would have if lifted through the atmosphere

AJAX Push Engine, an open source Comet/push server
ANSI/POSIX Environment, a POSIX compatibility layer for the Plan 9 operating system
APE tag, a tag format used to add metadata to digital audio files
.ape, a filename extension used by Monkey's Audio
APE100, a series of Italian supercomputers
Application Enhancer, a product by Unsanity
AVS plugin effect, any third-party addition to the Advanced Visualization Studio computer software
Auckland Peering Exchange, a peering point serving Auckland, New Zealand

Adapted physical education, for learners with a disability
Annual premium equivalent, a measure used for comparison of life insurance revenue
APE Foundation (Association for the Protection of the Environment)
APE, a stock market ticker for AMC Theatres, an American movie theater chain
Ape, Inc., a video game development company
Bukiyip language of Papua New Guinea (ISO 639 code: ape)
Hape people, an extinct Native American tribe